Gene-Based Algorithms for Heart Disease Treatment Developed in Russia
Russian researchers have developed treatment algorithms that tailor cardiovascular therapy to a patient’s genetic profile, requiring only a one-time genetic test.
Scientists at the Tsentr genomnykh issledovaniy mirovogo urovnya (World-Class Center for Genomic Research), part of the Petrovsky Russian Research Center of Surgery, have created algorithms to help cardiologists design treatment plans based on a patient’s genetic passport, the center’s press service said.
The approach allows doctors to prescribe medications based on how an individual’s body is expected to respond. This relies on pharmacogenetic testing.
For Safer Personalized Therapy
Not all cardiovascular drugs work equally well for every patient. Outcomes often depend on genetic traits. Doctors typically adjust medications and dosages based on lab results, but the new algorithm is designed to streamline that process. Patients would only need to take a genetic test once in their lifetime.
The algorithms are currently undergoing prospective studies and testing at a clinical research center. They could later be incorporated into clinical guidelines issued by Russia’s Health Ministry, with genetic testing covered under the national mandatory health insurance system. According to Sychev, the goal is to equip Russian cardiologists with this tool by 2030.
Researchers are also working to convert the algorithm into a dedicated software platform.
